San Luis Obispo, California
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For the county, see San Luis Obispo County.
San Luis Obispo (Spanish for St. Louis, Bishop of Tolosa) is a city in California, located roughly midway between San Francisco and Los Angeles on the Central Coast. The city, referred to locally as "SLO" or "San Luis," is the county seat of San Luis Obispo County. The 2000 census population was 44,174.